http://www.rimsntires.com/specspro.jsp
Comparing 165-65-14 4.5 +46 and 195-50-16 6.5 +45
Suspension clearance: Package 2 is 14 mm (0.6'') closer to suspension/brakes components. Acceptable for most cars.
Fenders clearance: Package 2 will stick out 16 mm (0.6'') farther. Make sure that you have enough room under the fender. If not, consider narrower tires or higher offset.
Wheelwells clearance: Will fill out the wheelwell by extra 16 mm. Make sure that you have enough room under the fender. If not, consider lower profiles or smaller rims.
SPEEDOMETER: When speedometer reads 60mph (96.6km/h) actual speed will be 63.4mph (102.1km/h): 5.7% faster.
Wheel and tire sizes are totally opinionated.
I like meat in my tires. That's just how I am. So I try to stick to tires with 50 series height. Any rim wider than 4.5 is going to look better than the stockies. For the look I want, on a 6.5 wide wheel, 205 looks great. However, our wheel wells are too small for 205s. For 6 inch wide wheels, 195 looks best IMO.
How do the wheels fit? Flush inside the fender? Poking out? Rear and front picture?