Last year, I remember this drive (around this area) was pretty hardcore for my rental. We rented a Toyota Corolla. It wasn't struggling but man, it was trying really hard to keep up with traffic speeds. Because there are spots where it's just going up.
Like others have said, I don't think it cause major issues unless you're really low on oil/fluids.
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View my fuel log 2015 Mirage DE 1.2 manual: 43.4 mpg (US) ... 18.5 km/L ... 5.4 L/100 km ... 52.2 mpg (Imp)