The different tires could be
part of the explanation.
Nothing has less rolling resistance than a
worn out Low Rolling Resistance (LRR) tire. So at the point your original tires needed to be replaced, they were actually producing the
least amount of rolling resistance...and the highest fuel mileage.
Even if you replaced them with the original style of tire, you would see a slight drop in mileage because the new tires have more tread (and more rolling resistance). You installed new tires...but you also changed to tires that were
not low rolling resistance.
So from a tire standpoint, you went from the least rolling resistance (a worn out LRR tire) to the most resistance (a new
non-LRR tire). In real terms...that one change might have cost you as much as 3-4 mpg.
There are lots of variables involved. And you are right...this car is sensitive to certain changes in driving conditions. I'll toss out a few ideas...
Is that a drive with a lot of hills? If so, that could account for some of it. This car doesn't like to climb hills. If you were climbing hills with the cruise control on, that would be even worse.
Were you running the air conditioning? That
really kills your mileage.
70-75mph? Forget about it...that's a mileage killer, too. The good mileage starts to fade above 60mph.
Do you have a CVT or a 5-speed? The 5-speed is going to be slightly better for fuel mileage.
Have the temperatures been cooler than usual out there? If so, that can also reduce your mileage.
Are you Ubering around with 3 400-pound passengers?
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